Dr. BHAWESH SAHA

Dr. RASHMI KUMARI, Dr. RASHMI KUMARI

Abstract

To compare the safety and efficacy of tacrolimus 0.03% ointment with cyclosporin 0.05% drops for subepithelial infiltrates (SEIs) following adenoviral keratoconjunctivitis (AK) arandomized, double blind trial was done.Grading of SEIs was done on a scale of 0 to 3. Consecutive patients with SEIs following AK were randomized to receive either topical tacrolimus 0.03% or Cyclosporin 0.05% drop twice daily for 6 months.A total of 46 patients each were assigned to the Tacro and Cyclo groups, respectively.Baseline characteristics were same.Significant change in symptoms, vision and SEIs in both the groups was noticed. However, the magnitude was greater in tacro group. Treatment was successful in 37 (92.5%) patients in Tacro and 34 (85%) patients in Cyclo group.6 (13.33%) eyes in tacro and 8 (17,7%) eyes in Cyclo group had recurrence of SEIs after cessation of therapy.Side effects like burning and irritation were noticed in both the groups but didn’t led to discontinuation of treatment.

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