Dr. SEEMA SEN

Prof.Dr. SEEMA KASHYAP, Dr. NEELAM PUSHKER, Dr.Shahzan Siddique

Abstract

Osteopontin (OPN) plays a major role in various cancers. ACC of the lacrimal gland is an aggressive tumor. We evaluated OPN expression by immunohistochemistry (IHC) in lacrimal gland ACC & correlated with clinicopathological features.Fourteen cases of lacrimal gland ACC , 34 months follow up available. There were 8 females & 6 males, mean age of 38 years (±25.8) and T stage (>T2) in 57% (8/14). Histologic patterns were cribriform (7), solid (5) and tubular in 2. Perineural invasion and recurrence were seen in 42% (6/14) each, systemic metastasis in 21% (3/14) & 3 patients with metastasis died. Overexpression of OPN seen in 43% (6/14). Fisher’s exact test showed significant correlation with perineural invasion (P= 0.03). Survival analysis showed no significant correlation.

Overexpression of OPN observed in 43% lacrimal gland ACC cases showed significant correlation with perineural invasion. A larger cohort of patients need to be studied for a more meaningful correlation