Dr.Priyarthi Pradhan

Dr.SHEELA P. KERKAR, Dr.ASHIYANA NARIANI, Dr.Shruti Jaiswal

Abstract

To date, there has been scarce data in the literature on pigmented ocular surface squamous neoplasia (OSSN) in patients with xeroderma pigmentosum (XP). This report highlights the case of a 4-year-old male with XP that presented with bilateral pigmented conjunctival squamous dysplasia. There was a prior history of white, peri-limbal focal dysplasia in the left eye that was treated with topical mitomycin-c. New conjunctival lesions appeared bilaterally 3 months later that were pigmented. Surgical excision was performed with wide margins, double freeze-thaw cryotherapy and amniotic membrane. Histopathology confirmed squamous dysplasia in both eyes and the patient was switched to topical interferon α-2B 1million IU/ml. Close follow-up was needed to identify these new lesions and multimodality treatment approaches were essential to effectively manage them. Anterior segment OCT, although not able to be done in this case, may further aid in the diagnosis of ocular melanotic lesions.