Dr.PAYEL KHATUA

Dr. SANJAY KUMAR DAULAT THAKUR, DR. AVIK DEY SARKAR, DR. SANCHARI SARKAR

Abstract

Objective: To compare Macular Thickness (MT) in patients with Choroidal Neovascularisation (CNV) after receiving Intravitreal Ranibizumab (IVR) following Monthly, Pro Re Nata (PRN) and Treat and Extend (T&E) protocol. Method: A prospective cohort study was conducted among 63 patients of CNV. IVR was given as per Monthly, PRN and T&E protocol with 21 patients in each group respectively. MT was measured pre-operatively and monthly for 6 months using Spectral Domain Optical Coherence Tomography. Results: Among 63 patients, the decrease in MT for Monthly, PRN and T&E protocol were 159.90±96.27µm, 91.33±59.75µm and 118.52±44.66µm respectively. Average no. of injections in Monthly, PRN and T&E protocol were 6, 4.67 and 3.10 respectively. The decrease in MT was statistically more significant in Monthly dosage than both T&E (p=0.01) and PRN (p=0.0005). It was also more in T&E than PRN (p=0.04). Conclusion: Monthly protocol of IVR was more efficient than T&E followed by PRN protocol for CNV.