Dr. PRABRISHA BANERJEE

DR. MD. SHAHID ALAM

Abstract

The application of cryotherapy on the surrounding tissues after removal of the lesion has become the mainstay in managing sebaceous gland carcinoma (SGC) of the eyelid. Cryotherapy destroys the tumor cells by direct injury and vascular stasis. In this prospective study involving 3 females and 2 males with the mean age of 63.8 ± 7.79 years, we have studied the effect of the direct injury on the SGC cells in vitro. Eyelid SGC with pagetoid growth was excluded from the study. A segment (specimen 2) was removed from the excised lesion (specimen 1) without disturbing the margins and was subjected to cryotherapy. Histopathology of the specimen 2 revealed more than 50% of viable tumor cells in all the cases. One case had recurrence after 1 year. It has been concluded that direct cell injury alone is inadequate in destroying the tumor cells and the vascular stasis secondary to that may also fail to do so. Hence, close monitoring of the cases is recommended in anticipation of recurrence.