Dr.ANNA PHILIP

Dr. SUNEETHA N LOBO, Dr.Mary Joseph

Abstract

Aim:A demyelinating disease with antibodies against Myelin-Oligodendrocyte Glycoprotein, frequently presents with atypical optic neuritis which is progressive with poor visual recovery. Aim is to describe optic nerve involvement & visual outcome in these patients

Method:Retrospective review of 18 MOG-antibody positive patients treated over 2years

Results:Mean age 38.7yrs, male:female ratio 4:5. Commonest presentation was bilateral optic neuritis 11/18(61%) patients;7/18 had no optic nerve involvement but had features of transverse myelitis and/or encephalomyelitis. All 11 with ON were steroid responders; 7/11(63.6%)were steroid dependent; 2/11 needed immunomodulators for recurrent optic neuritis. Visual outcomes:6/6vision(1), mild-moderate loss(9)&severe loss(≤6/60)(1); patient with 6/6 vision had perimetric changes.

Conclusion:Patients with anti-MOG antibodies who developed optic neuritis had bilateral involvement& most were steroid dependent with moderate residual visual loss.

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