Dr. Abhilash Sakam

Dr. S. GURUMURTHY

Abstract

Avellino corneal dystrophy is an inherited autosomal dominant caused by TGFB1 gene mutation. Patient presents with defective vision and recurrent corneal erosions. Clinically both granular and lattice lesions are seen . These lesions develop on the stroma before 20 yrs.On histology lesions have mixed deposits of amyloid and Hyaline.There is no cure for this condition and treatment usually focuses on alleviating symptoms, especially when vision becomes significantly impaired.Superficial debridement, lamellar keratoplasty, and excimer laser phototherapeutic keratectomy for superficial involvement and penetrating keratoplasty for deeper involvement.Recurrence may occur after keratoplasty.