Dr.Kshyanaprava priyadarshini

Dr. JAYASHREE DORA, Dr.Sharmistha Behera, Dr.Gopeswari Hota

Abstract

Xeroderma pigmentosa is a lethal precancerous condition primarily of the skin and mucous membranes. Ocular abnormalities are restricted to tissues exposed to ultraviolet radiation (lid, conjunctiva, and cornea) and neoplasms. A 21 year old female presented to us with irritation, watering, photophobia, foreign body sensation, pain associated with diminution of vision in both eyes. She presented with ulcerative blepharitis, lower lid ectropion (grade 1 ), conjunctivalization with anterior symblepharon, interstitial keratitis with both superficial & interstitial vascularization of the cornea in the florid stage with filamentary keratopathy. Similar condition was also found in the sibling. Association of a basal cell carcinoma was present in the right forehead and cheek region. Structural eyelid abnormalities, tear film abnormalities, ocular surface disease and inflammation, as well as corneal abnormalities was found in both the siblings